#  MCB65/MCB260: Physical Biochemistry: Understanding Macromolecular Machines 

 





 Semester:   Spring 

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 Link: [Course Website](https://beta.my.harvard.edu/course/MCB65/2026-Spring/001) 

 

 

 

This course develops your understanding of fundamental biochemistry concepts and how they are applied in cutting-edge structural and molecular biology research. You will learn about protein and nucleic acid structure, thermodynamics, kinetics, and intermolecular interactions while exploring techniques like cryo-electron microscopy, AlphaFold protein structure prediction, molecular dynamics, and protein design with Rosetta. The course emphasizes the application of these concepts to cell signaling, metabolism and drug-target interactions using interactive lectures and weekly sections. As part of section, students will undertake a discovery-based laboratory research project in which they will apply these course concepts toward understanding the structure and function of the ATPase domain of a transporter protein associated with antigen processing.